Immunogenicity and protective efficacy of a live attenuated vaccine against the 2009 pandemic A H1N1 in mice and ferrets.
Identifieur interne : 000C50 ( Main/Exploration ); précédent : 000C49; suivant : 000C51Immunogenicity and protective efficacy of a live attenuated vaccine against the 2009 pandemic A H1N1 in mice and ferrets.
Auteurs : Penghui Yang [République populaire de Chine] ; Yueqiang Duan ; Cheng Wang ; Li Xing ; Xiao Gao ; Chong Tang ; Deyan Luo ; Zhongpeng Zhao ; Weihong Jia ; Daxin Peng ; Xiufan Liu ; Xiliang WangSource :
- Vaccine [ 1873-2518 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Embryon de poulet, Femelle, Furets, Immunité muqueuse, Immunoglobuline A sécrétoire (immunologie), Muqueuse respiratoire (immunologie), Mutation, Rappel de vaccin (), Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Température, Vaccination (), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (immunologie), Virus recombinants (génétique), Virus recombinants (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués.
- génétique : Sous-type H1N1 du virus de la grippe A, Virus recombinants.
- immunologie : Immunoglobuline A sécrétoire, Muqueuse respiratoire, Sous-type H1N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Virus recombinants.
- Animaux, Embryon de poulet, Femelle, Furets, Immunité muqueuse, Mutation, Rappel de vaccin, Souris, Souris de lignée BALB C, Température, Vaccination.
English descriptors
- KwdEn :
- Animals, Chick Embryo, Female, Ferrets, Immunity, Mucosal, Immunization, Secondary (methods), Immunoglobulin A, Secretory (immunology), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Mice, Mice, Inbred BALB C, Mutation, Reassortant Viruses (genetics), Reassortant Viruses (immunology), Respiratory Mucosa (immunology), Temperature, Vaccination (methods), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (immunology).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- chemical , immunology : Immunoglobulin A, Secretory, Influenza Vaccines, Vaccines, Attenuated.
- genetics : Influenza A Virus, H1N1 Subtype, Reassortant Viruses.
- immunology : Influenza A Virus, H1N1 Subtype, Reassortant Viruses, Respiratory Mucosa.
- methods : Immunization, Secondary, Vaccination.
- Animals, Chick Embryo, Female, Ferrets, Immunity, Mucosal, Mice, Mice, Inbred BALB C, Mutation, Temperature.
Abstract
A novel 2009 influenza A (H1N1) virus was transmitted from humans to humans worldwide. The live attenuated monovalent A H1N1 vaccine (LAMV) for intranasal administration has shown promising immunogenicity and safety in clinical trials and for human use, but the experimental data based on LAMV is incomplete. In this study, using reverse genetic technology, we produced a cold-adapted (ca), live attenuated BJ/AA ca that contained hemagglutinin (HA) and neuraminidase (NA) genes from a 2009 pandemic A H1N1 isolate, A/Beijing/501/2009 virus (BJ501), and the remaining six internal gene segments from the cold-adapted influenza H2N2 A/Ann Arbor/6/60 virus (AA virus). BJ/AA ca exhibited phenotypes of temperature sensitivity (ts), ca, and attenuation (att). The candidate BJ/AA ca was immunogenic in mice and induced strong mucosal secretory IgA (sIgA) in the respiratory tract. Two dosages of intranasal immunization induced robust HI antibodies and offered efficient protection against challenge by the wild-type (wt) 2009 pandemic A H1N1 (A/Beijing/501/2009 or A/California/07/2009) in mice and ferrets. These results support the evaluation of this vaccine made from a wt strain isolated in China for clinical trials.
DOI: 10.1016/j.vaccine.2010.11.026
PubMed: 21111782
Affiliations:
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Le document en format XML
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sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name></author><author><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name></author><author><name sortKey="Gao, Xiao" sort="Gao, Xiao" uniqKey="Gao X" first="Xiao" last="Gao">Xiao Gao</name></author><author><name sortKey="Tang, Chong" sort="Tang, Chong" uniqKey="Tang C" first="Chong" last="Tang">Chong Tang</name></author><author><name sortKey="Luo, Deyan" sort="Luo, Deyan" uniqKey="Luo D" first="Deyan" last="Luo">Deyan Luo</name></author><author><name sortKey="Zhao, Zhongpeng" sort="Zhao, Zhongpeng" uniqKey="Zhao Z" first="Zhongpeng" last="Zhao">Zhongpeng Zhao</name></author><author><name sortKey="Jia, Weihong" sort="Jia, Weihong" uniqKey="Jia W" first="Weihong" last="Jia">Weihong Jia</name></author><author><name sortKey="Peng, Daxin" sort="Peng, Daxin" uniqKey="Peng D" first="Daxin" last="Peng">Daxin Peng</name></author><author><name sortKey="Liu, Xiufan" sort="Liu, 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type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Duan, Yueqiang" sort="Duan, Yueqiang" uniqKey="Duan Y" first="Yueqiang" last="Duan">Yueqiang Duan</name></author><author><name sortKey="Wang, Cheng" sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name></author><author><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name></author><author><name sortKey="Gao, Xiao" sort="Gao, Xiao" uniqKey="Gao X" first="Xiao" last="Gao">Xiao Gao</name></author><author><name sortKey="Tang, Chong" sort="Tang, Chong" uniqKey="Tang C" first="Chong" last="Tang">Chong Tang</name></author><author><name sortKey="Luo, Deyan" sort="Luo, Deyan" uniqKey="Luo D" first="Deyan" last="Luo">Deyan Luo</name></author><author><name sortKey="Zhao, Zhongpeng" sort="Zhao, Zhongpeng" uniqKey="Zhao Z" first="Zhongpeng" last="Zhao">Zhongpeng Zhao</name></author><author><name sortKey="Jia, Weihong" sort="Jia, Weihong" 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Virus, H1N1 Subtype (immunology)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mutation</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (immunology)</term><term>Respiratory Mucosa (immunology)</term><term>Temperature</term><term>Vaccination (methods)</term><term>Vaccines, Attenuated (administration & dosage)</term><term>Vaccines, Attenuated (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Embryon de poulet</term><term>Femelle</term><term>Furets</term><term>Immunité muqueuse</term><term>Immunoglobuline A sécrétoire (immunologie)</term><term>Muqueuse respiratoire (immunologie)</term><term>Mutation</term><term>Rappel de vaccin ()</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Température</term><term>Vaccination ()</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (administration et posologie)</term><term>Vaccins atténués (immunologie)</term><term>Virus recombinants (génétique)</term><term>Virus recombinants (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Immunoglobulin A, Secretory</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 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BALB C</term><term>Mutation</term><term>Temperature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Embryon de poulet</term><term>Femelle</term><term>Furets</term><term>Immunité muqueuse</term><term>Mutation</term><term>Rappel de vaccin</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Température</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A novel 2009 influenza A (H1N1) virus was transmitted from humans to humans worldwide. The live attenuated monovalent A H1N1 vaccine (LAMV) for intranasal administration has shown promising immunogenicity and safety in clinical trials and for human use, but the experimental data based on LAMV is incomplete. In this study, using reverse genetic technology, we produced a cold-adapted (ca), live attenuated BJ/AA ca that contained hemagglutinin (HA) and neuraminidase (NA) genes from a 2009 pandemic A H1N1 isolate, A/Beijing/501/2009 virus (BJ501), and the remaining six internal gene segments from the cold-adapted influenza H2N2 A/Ann Arbor/6/60 virus (AA virus). BJ/AA ca exhibited phenotypes of temperature sensitivity (ts), ca, and attenuation (att). The candidate BJ/AA ca was immunogenic in mice and induced strong mucosal secretory IgA (sIgA) in the respiratory tract. Two dosages of intranasal immunization induced robust HI antibodies and offered efficient protection against challenge by the wild-type (wt) 2009 pandemic A H1N1 (A/Beijing/501/2009 or A/California/07/2009) in mice and ferrets. These results support the evaluation of this vaccine made from a wt strain isolated in China for clinical trials.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Duan, Yueqiang" sort="Duan, Yueqiang" uniqKey="Duan Y" first="Yueqiang" last="Duan">Yueqiang Duan</name><name sortKey="Gao, Xiao" sort="Gao, Xiao" uniqKey="Gao X" first="Xiao" last="Gao">Xiao Gao</name><name sortKey="Jia, Weihong" sort="Jia, Weihong" uniqKey="Jia W" first="Weihong" last="Jia">Weihong Jia</name><name sortKey="Liu, Xiufan" sort="Liu, Xiufan" uniqKey="Liu X" first="Xiufan" last="Liu">Xiufan Liu</name><name sortKey="Luo, Deyan" sort="Luo, Deyan" uniqKey="Luo D" first="Deyan" last="Luo">Deyan Luo</name><name sortKey="Peng, Daxin" sort="Peng, Daxin" uniqKey="Peng D" first="Daxin" last="Peng">Daxin Peng</name><name sortKey="Tang, Chong" sort="Tang, Chong" uniqKey="Tang C" first="Chong" last="Tang">Chong Tang</name><name sortKey="Wang, Cheng" sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name><name sortKey="Zhao, Zhongpeng" sort="Zhao, Zhongpeng" uniqKey="Zhao Z" first="Zhongpeng" last="Zhao">Zhongpeng Zhao</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Penghui" sort="Yang, Penghui" uniqKey="Yang P" first="Penghui" last="Yang">Penghui Yang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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